Mean Kinetic Temperature Calculator Mkt

This Excel template developed by Vacker UAE calculates Mean Kinetic Value (MKT) for temperature sensitive products.

1. Mean Kinetic Temperature Formula
2. Mean Kinetic Temperature Calculator
3. Mean Kinetic Temperature Excel

Mean kinetic temperature (MKT) is a simplified way of expressing the overall effect of temperature fluctuations during storage or transit of perishable goods. The MKT is widely used in the pharmaceutical industry.

The mean kinetic temperature can be expressed as:

${\displaystyle T_K=\frac{\frac{\mathrm{\Delta }H}{R}}{-\ln \left(\frac{t_1{e}^{\left(\frac{-\mathrm{\Delta }H}{R{T}_1}\right)}+t_2{e}^{\left(\frac{-\mathrm{\Delta }H}{R{T}_2}\right)}+\cdots +t_n{e}^{\left(\frac{-\mathrm{\Delta }H}{R{T}_n}\right)}}{t_1+t_2+\cdots +t_n}\right)}}$

Where:

${\displaystyle T_K}$ is the mean kinetic temperature in kelvins

${\displaystyle \mathrm{\Delta }H}$ is the activation energy (in kJ mol⁻¹)

${\displaystyle R}$ is the gas constant (in J mol⁻¹ K⁻¹)

${\displaystyle T_1}$ to ${\displaystyle T_n}$ are the temperatures at each of the sample points in kelvins

${\displaystyle t_1}$ to ${\displaystyle t_n}$ are time intervals at each of the sample points

When the temperature readings are taken at the same interval (i.e., ${\displaystyle t_1}$ = ${\displaystyle t_2}$ = ${\displaystyle \cdots }$ = ${\displaystyle t_n}$), the above equation is reduced to:

${\displaystyle T_K=\frac{\frac{\mathrm{\Delta }H}{R}}{-\ln \left(\frac{e^{\left(\frac{-\mathrm{\Delta }H}{R{T}_1}\right)}+e^{\left(\frac{-\mathrm{\Delta }H}{R{T}_2}\right)}+\cdots +e^{\left(\frac{-\mathrm{\Delta }H}{R{T}_n}\right)}}{n}\right)}}$

Where:

${\displaystyle n}$ is the number of temperature sample points

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In the event of a temperature deviation, the wholesale authorisation holder should seek advice from the marketing authorisation holder of the medicinal item in question.

One very interesting Q A refers to Mean Kinetic Temperature Calculations (MKT).

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In other words, MKT is download a calculated, single temperature that is analogous to the effects of temperature variations over a period of time.

Mean Kinetic Temperature Calculator addresses a very small group of users, typically physicists, that are on the lookout for a rapid calculator for the MKT (mean kinetic temperature).

Moreover, you also get a gas constant as well as sample-related values.

Furthermore, the MKT value is, originally, calculated in Kelvins, the standard temperature measurement unit within the SI system (International System of Units).

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To sum it all up, the Mean Kinetic Temperature Calculator program can prove to be a must-have addition norton to the software arsenal of a few users, due to its rather exclusivist approach to the matter.

Therefore, MKT provides for the non-linear effect of temperature.

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Mean Kinetic Temperature Formula

Technically speaking, MKT is an expression of cumulative thermal stress experienced by a product at varying temperatures during storage and distribution.

Using MKT we can calculate that the temperature profile of the eggs was thermally equivalent to storing them at 10.096C for 7 hours.

Of course, mean kinetic temperature values can also be manually calculated, but that can prove to be a time-consuming activity, as the formula for this certain unit is quite impressive.

It is not possible to obtain a meaningful MKT value from daily readings of simple max / min thermometers as temperature fluctuation is not a linear function.

Consider the following example: EXAMPLE : A dozen eggs sat: In a 20C room for 2 hours.

The International Conference on Harmonization (ICH) stability testing guidelines define MKT as a single derived temperature which, if maintained over a defined period, would afford the same thermal challenge to a pharmaceutical product as would have been experienced over a range of both higher and lower temperatures for an equivalent defined period.

The MKT is widely used in the pharmaceutical industry.

Mean kinetic temperature is a simplified way of expressing the overall effect of temperature fluctuations during storage or transit of perishable goods.

Mean Kinetic Temperature Calculator

According to Pharmacopeia definition the MKT 'is defined as the single calculated temperature at which the total amount of degradation over a particular period is equal to the sum of the individual degradations that would occur at various temperatures.' According to MHRA : 'Mean Kinetic Temperature (MKT) should not be used to compensate for poor.

Mean Kinetic Temperature Excel

It may be applied in situations where control is good but where occasional excursions may be encountered.